Open AccessTransforming brain signals related to value evaluation and self‐control into behavioral choices
Author(s) -
Zha Rujing,
Bu Junjie,
Wei Zhengde,
Han Long,
Zhang Pengyu,
Ren Jiecheng,
Li JiAn,
Wang Ying,
Yang Lizhuang,
VollstädtKlein Sabine,
Zhang Xiaochu
Publication year - 2019
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24379
Subject(s) - ventromedial prefrontal cortex , impulsivity , psychology , dorsolateral prefrontal cortex , ventral striatum , striatum , functional magnetic resonance imaging , addiction , prefrontal cortex , intertemporal choice , cognitive psychology , neuroscience , orbitofrontal cortex , discounting , cognition , developmental psychology , finance , dopamine , economics , econometrics
Abstract The processes involved in value evaluation and self‐control are critical when making behavioral choices. However, the evidence linking these two types of processes to behavioral choices in intertemporal decision‐making remains elusive. As the ventromedial prefrontal cortex (vmPFC), striatum, and dorsolateral prefrontal cortex (dlPFC) have been associated with these two processes, we focused on these three regions. We employed functional magnetic resonance imaging during a delayed discounting task (DDT) using a relatively large sample size, three independent samples. We evaluated how much information about a specific choice could be decoded from local patterns in each brain area using multivoxel pattern analysis (MVPA). To investigate the relationship between the dlPFC and vmPFC/striatum regions, we performed a psychophysiological interaction (PPI) analysis. In Experiment I, we found that the vmPFC and dlPFC, but not the striatum, could determine choices in healthy participants. Furthermore, we found that the dlPFC showed significant functional connectivity with the vmPFC, but not the striatum, when making decisions. These results could be replicated in Experiment II with an independent sample of healthy participants. In Experiment III, the choice‐decoding accuracy in the vmPFC and dlPFC was lower in patients with addiction (smokers and participants with Internet gaming disorder) than in healthy participants, and decoding accuracy in the dlPFC was related to impulsivity in addicts. Taken together, our findings may provide neural evidence supporting the hypothesis that value evaluation and self‐control processes both guide the intertemporal choices, and might provide potential neural targets for the diagnosis and treatment of impulsivity‐related brain disorders.