Open AccessMapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task
Author(s) -
Cao Zhipeng,
Bennett Marc,
Orr Catherine,
Icke Ilknur,
Banaschewski Tobias,
Barker Gareth J.,
Bokde Arun L. W.,
Bromberg Uli,
Büchel Christian,
Quinlan Erin Burke,
Desrivières Sylvane,
Flor Herta,
Frouin Vincent,
Garavan Hugh,
Gowland Penny,
Heinz Andreas,
Ittermann Bernd,
Martinot JeanLuc,
Nees Frauke,
Orfanos Dimitri Papadopoulos,
Paus Tomáš,
Poustka Luise,
Hohmann Sarah,
Fröhner Juliane H.,
Smolka Michael N.,
Walter Henrik,
Schumann Gunter,
Whelan Robert
Publication year - 2019
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24370
Subject(s) - psychology , precuneus , functional magnetic resonance imaging , reward dependence , neuroscience , putamen , ventromedial prefrontal cortex , reward system , ventral striatum , insula , anticipation (artificial intelligence) , posterior cingulate , brain mapping , ventrolateral prefrontal cortex , striatum , novelty seeking , prefrontal cortex , cognition , personality , social psychology , artificial intelligence , computer science , dopamine , temperament
The functional neuroanatomy and connectivity of reward processing in adults are well documented, with relatively less research on adolescents, a notable gap given this developmental period's association with altered reward sensitivity. Here, a large sample ( n = 1,510) of adolescents performed the monetary incentive delay (MID) task during functional magnetic resonance imaging. Probabilistic maps identified brain regions that were reliably responsive to reward anticipation and receipt, and to prediction errors derived from a computational model. Psychophysiological interactions analyses were used to examine functional connections throughout reward processing. Bilateral ventral striatum, pallidum, insula, thalamus, hippocampus, cingulate cortex, midbrain, motor area, and occipital areas were reliably activated during reward anticipation. Bilateral ventromedial prefrontal cortex and bilateral thalamus exhibited positive and negative activation, respectively, during reward receipt. Bilateral ventral striatum was reliably active following prediction errors. Previously, individual differences in the personality trait of sensation seeking were shown to be related to individual differences in sensitivity to reward outcome. Here, we found that sensation seeking scores were negatively correlated with right inferior frontal gyrus activity following reward prediction errors estimated using a computational model. Psychophysiological interactions demonstrated widespread cortical and subcortical connectivity during reward processing, including connectivity between reward‐related regions with motor areas and the salience network. Males had more activation in left putamen, right precuneus, and middle temporal gyrus during reward anticipation. In summary, we found that, in adolescents, different reward processing stages during the MID task were robustly associated with distinctive patterns of activation and of connectivity.