Open AccessFrom simultaneous to synergistic MR‐PET brain imaging: A review of hybrid MR‐PET imaging methodologies
Author(s) -
Chen Zhaolin,
Jamadar Sharna D.,
Li Shenpeng,
Sforazzini Francesco,
Baran Jakub,
Ferris Nicholas,
Shah Nadim Jon,
Egan Gary F.
Publication year - 2018
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24314
Subject(s) - neuroimaging , positron emission tomography , magnetic resonance imaging , computer science , correction for attenuation , medical physics , artificial intelligence , medicine , neuroscience , nuclear medicine , psychology , radiology
Simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scanning is a recent major development in biomedical imaging. The full integration of the PET detector ring and electronics within the MR system has been a technologically challenging design to develop but provides capacity for simultaneous imaging and the potential for new diagnostic and research capability. This article reviews state‐of‐the‐art MR‐PET hardware and software, and discusses future developments focusing on neuroimaging methodologies for MR‐PET scanning. We particularly focus on the methodologies that lead to an improved synergy between MRI and PET, including optimal data acquisition, PET attenuation and motion correction, and joint image reconstruction and processing methods based on the underlying complementary and mutual information. We further review the current and potential future applications of simultaneous MR‐PET in both systems neuroscience and clinical neuroimaging research. We demonstrate a simultaneous data acquisition protocol to highlight new applications of MR‐PET neuroimaging research studies.