Open AccessStriatal subdivisions that coherently interact with multiple cerebrocortical networks
Author(s) -
Ogawa Akitoshi,
Osada Takahiro,
Tanaka Masaki,
Hori Masaaki,
Aoki Shigeki,
Nikolaidis Aki,
Milham Michael P.,
Konishi Seiki
Publication year - 2018
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24275
Subject(s) - striatum , basal ganglia , neuroscience , subdivision , cerebral cortex , cortex (anatomy) , ventral striatum , human brain , biology , psychology , central nervous system , dopamine , geography , archaeology
The striatum constitutes the cortical‐basal ganglia loop and receives input from the cerebral cortex. Previous MRI studies have parcellated the human striatum using clustering analyses of structural/functional connectivity with the cerebral cortex. However, it is currently unclear how the striatal regions functionally interact with the cerebral cortex to organize cortical functions in the temporal domain. In the present human functional MRI study, the striatum was parcellated using boundary mapping analyses to reveal the fine architecture of the striatum by focusing on local gradient of functional connectivity. Boundary mapping analyses revealed approximately 100 subdivisions of the striatum. Many of the striatal subdivisions were functionally connected with specific combinations of cerebrocortical functional networks, such as somato‐motor (SM) and ventral attention (VA) networks. Time‐resolved functional connectivity analyses further revealed coherent interactions of multiple connectivities between each striatal subdivision and the cerebrocortical networks (i.e., a striatal subdivision‐SM connectivity and the same striatal subdivision‐VA connectivity). These results suggest that the striatum contains a large number of subdivisions that mediate functional coupling between specific combinations of cerebrocortical networks.