Open AccessDetailed view on slow sinusoidal, hemodynamic oscillations on the human brain cortex by F ourier transforming oxy/deoxy hyperspectral images
Author(s) -
Noordmans H.J.,
van Blooijs D.,
Siero J.C.W.,
Zwanenburg J.J.M.,
Klaessens J.H.G.M.,
Ramsey N. F.
Publication year - 2018
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24194
Subject(s) - neuroscience , hyperspectral imaging , hemodynamics , cortex (anatomy) , cerebral cortex , brain cortex , physics , psychology , artificial intelligence , biology , computer science , medicine , endocrinology
Abstract Slow sinusoidal, hemodynamic oscillations (SSHOs) around 0.1 Hz are frequently seen in mammalian and human brains. In four patients undergoing epilepsy surgery, subtle but robust fluctuations in oxy‐ and deoxyhemoglobin were detected using hyperspectral imaging of the cortex. These SSHOs were stationary during the entire 4 to 10 min acquisition time. By Fourier filtering the oxy‐ and deoxyhemoglobin time signals with a small bandwidth, SSHOs became visible within localized regions of the brain, with distinctive frequencies and a continuous phase variation within that region. SSHOs of deoxyhemoglobin appeared to have an opposite phase and 11% smaller amplitude with respect to the oxyhemoglobin SSHOs. Although the origin of SSHOs remains unclear, we find indications that the observed SSHOs may embody a local propagating hemodynamic wave with velocities in line with capillary blood velocities, and conceivably related to vasomotion and maintenance of adequate tissue perfusion. Hyperspectral imaging of the human cortex during surgery allow in‐depth characterization of SSHOs, and may give further insight in the nature and potential (clinical) use of SSHOs.