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The retinal ganglion cell layer predicts normal‐appearing white matter tract integrity in multiple sclerosis: A combined diffusion tensor imaging and optical coherence tomography approach
Author(s) -
Alves Carolina,
Batista Sónia,
d'Almeida Otília C.,
Sousa Lívia,
Cunha Luís,
Bernardes Rui,
CasteloBranco Miguel
Publication year - 2018
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23946
Subject(s) - diffusion mri , optic neuritis , white matter , nerve fiber layer , inner plexiform layer , ganglion cell layer , retinal , ophthalmology , optical coherence tomography , multiple sclerosis , optic nerve , optic tract , receiver operating characteristic , pathology , medicine , magnetic resonance imaging , radiology , psychiatry
We investigated the relationship between retinal layers and normal‐appearing white matter (WM) integrity in the brain of patients with relapsing‐remitting multiple sclerosis (MS), using a combined diffusion tensor imaging and high resolution optical coherence tomography approach. Fifty patients and 62 controls were recruited. The patients were divided into two groups according to presence ( n  = 18) or absence ( n  = 32) of optic neuritis. Diffusion tensor data were analyzed with a voxel‐wise whole brain analysis of diffusion metrics in WM with tract‐based spatial statistics. Thickness measurements were obtained for each individual retinal layer. Partial correlation and multivariate regression analyses were performed, assessing the association between individual retinal layers and diffusion metrics across all groups. Region‐based analysis was performed, by focusing on tracts associated with the visual system. Receiver operating characteristic (ROC) curves were computed to compare the biomarker potential for the diagnosis of MS, using the thickness of each retinal layer and diffusion metrics. In patients without optic neuritis, both ganglion cell layer (GCL) and inner plexiform layer thickness correlated with the diffusion metrics within and outside the visual system. GCL thickness was a significant predictor of diffusion metrics in the whole WM skeleton, unlike other layers. No association was observed for either controls or patients with a history of optic neuritis. ROC analysis showed that the biomarker potential for the diagnosis of MS based on the GCL was high when compared to other layers. We conclude that GCL integrity is a predictor of whole‐brain WM disruption in MS patients without optic neuritis.

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