Open AccessMapping the structural and functional network architecture of the medial temporal lobe using 7T MRI
Author(s) -
Shah Preya,
Bassett Danielle S.,
Wisse Laura E.M.,
Detre John A.,
Stein Joel M.,
Yushkevich Paul A.,
Shinohara Russell T.,
Pluta John B.,
Valenciano Elijah,
Daffner Molly,
Wolk David A.,
Elliott Mark A.,
Litt Brian,
Davis Kathryn A.,
Das Sandhitsu R.
Publication year - 2018
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23887
Subject(s) - subiculum , neuroscience , parahippocampal gyrus , hippocampal formation , temporal lobe , psychology , dentate gyrus , epilepsy
Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in healthy subjects ( n = 31) using both resting state functional MRI and MTL‐focused T2‐weighted structural MRI at 7 tesla. Ten MTL subregions per hemisphere, including hippocampal subfields and cortical regions of the parahippocampal gyrus, were segmented for each subject using a multi‐atlas algorithm. Both structural covariance matrices from correlations of subregion volumes across subjects, and functional connectivity matrices from correlations between subregion BOLD time series were generated. We found a moderate structural and strong functional inter‐hemispheric symmetry. Several bilateral hippocampal subregions (CA1, dentate gyrus, and subiculum) emerged as functional network hubs. We also observed that the structural and functional networks naturally separated into two modules closely corresponding to (a) bilateral hippocampal formations, and (b) bilateral extra‐hippocampal structures. Finally, we found a significant correlation in structural and functional connectivity ( r = 0.25). Our findings represent a comprehensive analysis of network topology of the MTL at the subregion level. We share our data, methods, and findings as a reference for imaging methods and disease‐based research.