Open AccessMultifaceted brain networks reconfiguration in disorders of consciousness uncovered by co‐activation patterns
Author(s) -
Di Perri Carol,
Amico Enrico,
Heine Lizette,
Annen Jitka,
Martial Charlotte,
Larroque Stephen Karl,
Soddu Andrea,
Marinazzo Daniele,
Laureys Steven
Publication year - 2018
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23826
Subject(s) - default mode network , posterior cingulate , dynamic functional connectivity , neuroscience , wakefulness , persistent vegetative state , pathological , psychology , cortex (anatomy) , resting state fmri , control reconfiguration , functional magnetic resonance imaging , consciousness , minimally conscious state , medicine , electroencephalography , computer science , embedded system
Given that recent research has shown that functional connectivity is not a static phenomenon, we aim to investigate the dynamic properties of the default mode network's (DMN) connectivity in patients with disorders of consciousness. Methods Resting‐state fMRI volumes of a convenience sample of 17 patients in unresponsive wakefulness syndrome (UWS) and controls were reduced to a spatiotemporal point process by selecting critical time points in the posterior cingulate cortex (PCC). Spatial clustering was performed on the extracted PCC time frames to obtain 8 different co‐activation patterns (CAPs). We investigated spatial connectivity patterns positively and negatively correlated with PCC using both CAPs and standard stationary method. We calculated CAPs occurrences and the total number of frames. Results Compared to controls, patients showed (i) decreased within‐network positive correlations and between‐network negative correlations, (ii) emergence of “pathological” within‐network negative correlations and between‐network positive correlations (better defined with CAPs), and (iii) “pathological” increases in within‐network positive correlations and between‐network negative correlations (only detectable using CAPs). Patients showed decreased occurrence of DMN‐like CAPs (1–2) compared to controls. No between‐group differences were observed in the total number of frames Conclusion CAPs reveal at a more fine‐grained level the multifaceted spatial connectivity reconfiguration following the DMN disruption in UWS patients, which is more complex than previously thought and suggests alternative anatomical substrates for consciousness. BOLD fluctuations do not seem to differ between patients and controls, suggesting that BOLD response represents an intrinsic feature of the signal, and therefore that spatial configuration is more important for consciousness than BOLD activation itself. Hum Brain Mapp 39:89–103, 2018 . © 2017 Wiley Periodicals, Inc.