Open AccessEvidence‐based source modeling of nociceptive cortical responses: A direct comparison of scalp and intracranial activity in humans
Author(s) -
Bradley Claire,
Bastuji Hélène,
GarciaLarrea Luis
Publication year - 2017
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23812
Subject(s) - scalp , electroencephalography , neuroscience , insular cortex , psychology , nociception , cingulate cortex , supplementary motor area , brain mapping , brain activity and meditation , anterior cingulate cortex , functional magnetic resonance imaging , anatomy , medicine , cognition , central nervous system , receptor
Abstract Background Source modeling of EEG traditionally relies on interplay between physiological hypotheses and mathematical estimates. We propose to optimize the process by using evidence gathered from brain imaging and intracortical recordings. Methods We recorded laser‐evoked potentials in 18 healthy participants, using high‐density EEG. Brain sources were modeled during the first second poststimulus, constraining their initial position to regions where nociceptive‐related activity has been ascertained by intracranial EEG. These comprised the two posterior operculo‐insular regions, primary sensorimotor, posterior parietal, anterior cingulate/supplementary motor (ACC/SMA), bilateral frontal/anterior insular, and posterior cingulate (PCC) cortices. Results The model yielded an average goodness of fit of 91% for individual and 95.8% for grand‐average data. When compared with intracranial recordings from 27 human subjects, no significant difference in peak latencies was observed between modeled and intracranial data for 5 of the 6 assessable regions. Morphological match was excellent for operculo‐insular, frontal, ACC/SMA and PCC regions (cross‐correlation > 0.7) and fair for sensori‐motor and posterior parietal cortex (c‐c ∼ 0.5). Conclusions Multiple overlapping activities evoked by nociceptive input can be disentangled from high‐density scalp EEG guided by intracranial data. Modeled sources accurately described the timing and morphology of most activities recorded with intracranial electrodes, including those coinciding with the emergence of stimulus awareness. Hum Brain Mapp 38:6083–6095, 2017 . © 2017 Wiley Periodicals, Inc.