Open AccessSeparate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition
Author(s) -
Deng Wanlu,
Rolls Edmund T.,
Ji Xiaoxi,
Robbins Trevor W.,
Banaschewski Tobias,
Bokde Arun L. W.,
Bromberg Uli,
Buechel Christian,
Desrivières Sylvane,
Conrod Patricia,
Flor Herta,
Frouin Vincent,
Gallinat Juergen,
Garavan Hugh,
Gowland Penny,
Heinz Andreas,
Ittermann Bernd,
Martinot JeanLuc,
Lemaitre Herve,
Nees Frauke,
Papadopoulos Orfanos Dimitri,
Poustka Luise,
Smolka Michael N.,
Walter Henrik,
Whelan Robert,
Schumann Gunter,
Feng Jianfeng
Publication year - 2017
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23607
Subject(s) - anterior cingulate cortex , neuroscience , dorsolateral prefrontal cortex , orbitofrontal cortex , psychology , prefrontal cortex , insula , stop signal , brain activity and meditation , electroencephalography , cognition , engineering , electrical engineering , latency (audio)
To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop‐signal task, in 1709 participants. First, areas activated more in stop‐success (SS) than stop‐failure (SF) included the lateral orbitofrontal cortex (OFC) extending into the inferior frontal gyrus (ventrolateral prefrontal cortex, BA 47/12), and the dorsolateral prefrontal cortex (DLPFC). Second, the anterior cingulate and anterior insula (AI) were activated more on failure trials, specifically in SF versus SS. The interaction between brain region and SS versus SF activations was significant ( P = 5.6 * 10 −8 ). The results provide new evidence from this “big data” investigation consistent with the hypotheses that the lateral OFC is involved in the stop‐related processing that inhibits the action; that the DLPFC is involved in attentional processes that influence task performance; and that the AI and anterior cingulate are involved in emotional processes when failure occurs. The investigation thus emphasizes the role of the human lateral OFC BA 47/12 in changing behavior, and inhibiting behavior when necessary. A very similar area in BA47/12 is involved in changing behavior when an expected reward is not obtained, and has been shown to have high functional connectivity in depression. Hum Brain Mapp 38:3527–3537, 2017 . © 2017 Wiley Periodicals, Inc.