Open AccessThe impact of parkinson's disease on the cortical mechanisms that support auditory–motor integration for voice control
Author(s) -
Huang Xiyan,
Chen Xi,
Yan Nan,
Jones Jeffery A.,
Wang Emily Q.,
Chen Ling,
Guo Zhiqiang,
Li Weifeng,
Liu Peng,
Liu Hanjun
Publication year - 2016
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23306
Subject(s) - inferior parietal lobule , psychology , audiology , inferior frontal gyrus , superior temporal gyrus , premotor cortex , middle frontal gyrus , neuroscience , postcentral gyrus , middle temporal gyrus , auditory feedback , functional magnetic resonance imaging , sensory system , neural substrate , somatosensory system , medicine , cognition , anatomy , dorsum
Several studies have shown sensorimotor deficits in speech processing in individuals with idiopathic Parkinson's disease (PD). The underlying neural mechanisms, however, remain poorly understood. In the present event‐related potential (ERP) study, 18 individuals with PD and 18 healthy controls were exposed to frequency‐altered feedback (FAF) while producing a sustained vowel and listening to the playback of their own voice. Behavioral results revealed that individuals with PD produced significantly larger vocal compensation for pitch feedback errors than healthy controls, and exhibited a significant positive correlation between the magnitude of their vocal responses and the variability of their unaltered vocal pitch. At the cortical level, larger P2 responses were observed for individuals with PD compared with healthy controls during active vocalization due to left‐lateralized enhanced activity in the superior and inferior frontal gyrus, premotor cortex, inferior parietal lobule, and superior temporal gyrus. These two groups did not differ, however, when they passively listened to the playback of their own voice. Individuals with PD also exhibited larger P2 responses during active vocalization when compared with passive listening due to enhanced activity in the inferior frontal gyrus, precental gyrus, postcentral gyrus, and middle temporal gyrus. This enhancement effect, however, was not observed for healthy controls. These findings provide neural evidence for the abnormal auditory–vocal integration for voice control in individuals with PD, which may be caused by their deficits in the detection and correction of errors in voice auditory feedback. Hum Brain Mapp 37:4248–4261, 2016 . © 2016 Wiley Periodicals, Inc.