Open AccessStructural connectivity of the human anterior temporal lobe: A diffusion magnetic resonance imaging study
Author(s) -
Papinutto Nico,
Galantucci Sebastiano,
Mandelli Maria Luisa,
Gesierich Benno,
Jovicich Jorge,
Caverzasi Eduardo,
Henry Roland G.,
Seeley William W.,
Miller Bruce L.,
Shapiro Kevin A.,
GornoTempini Maria Luisa
Publication year - 2016
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23167
Subject(s) - arcuate fasciculus , tractography , diffusion mri , neuroscience , temporal lobe , psychology , lateralization of brain function , inferior temporal gyrus , functional magnetic resonance imaging , cognition , anatomy , magnetic resonance imaging , biology , medicine , epilepsy , radiology
The anterior temporal lobes (ATL) have been implicated in a range of cognitive functions including auditory and visual perception, language, semantic knowledge, and social‐emotional processing. However, the anatomical relationships between the ATLs and the broader cortical networks that subserve these functions have not been fully elucidated. Using diffusion tensor imaging (DTI) and probabilistic tractography, we tested the hypothesis that functional segregation of information in the ATLs is reflected by distinct patterns of structural connectivity to regions outside the ATLs. We performed a parcellation of the ATLs bilaterally based on the degree of connectivity of each voxel with eight ipsilateral target regions known to be involved in various cognitive networks. Six discrete segments within each ATL showed preferential connectivity to one of the ipsilateral target regions, via four major fiber tracts (uncinate, inferior longitudinal, middle longitudinal, and arcuate fasciculi). Two noteworthy interhemispheric differences were observed: connections between the ATL and orbito‐frontal areas were stronger in the right hemisphere, while the consistency of the connection between the ATL and the inferior frontal gyrus through the arcuate fasciculus was greater in the left hemisphere. Our findings support the hypothesis that distinct regions within the ATLs have anatomical connections to different cognitive networks. Hum Brain Mapp 37:2210–2222, 2016 . © 2016 Wiley Periodicals, Inc.