Open AccessDynamic thalamus parcellation from resting‐state fMRI data
Author(s) -
Ji Bing,
Li Zhihao,
Li Kaiming,
Li Longchuan,
Langley Jason,
Shen Hui,
Nie Shengdong,
Zhang Renjie,
Hu Xiaoping
Publication year - 2016
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23079
Subject(s) - thalamus , neuroscience , resting state fmri , neuroimaging , dynamic functional connectivity , functional connectivity , cortex (anatomy) , psychology
Abstract The thalamus is a relay center between various subcortical brain areas and the cerebral cortex with delineation of its constituent nuclei being of particular interest in many applications. While previous studies have demonstrated efficacy of connectivity‐based thalamus segmentation, they used approaches that do not consider the dynamic nature of thalamo‐cortical interactions. In this study, we explicitly exploited the dynamic variation of thalamo‐cortical connections to identify different states of functional connectivity and performed state‐specific thalamus parcellation. With normalized spectral clustering successively applied in temporal and spatial domains, nine thalamo‐cortical connectivity states were identified and the dynamic thalamus parcellation revealed finer thalamic structures with improved atlas correspondence. The present results extend our understanding of thalamo‐cortical connectivity and provide a more comprehensive view of the thalamo‐cortical interaction. Hum Brain Mapp 37:954–967, 2016 . © 2015 Wiley Periodicals, Inc .