Open AccessDBS proc: An open source process for DBS electrode localization and tractographic analysis
Author(s) -
Lauro Peter M.,
VanegasArroyave Nora,
Huang Ling,
Taylor Paul A.,
Zaghloul Kareem A.,
Lungu Codrin,
Saad Ziad S.,
Horovitz Silvina G.
Publication year - 2016
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.23039
Subject(s) - deep brain stimulation , movement disorders , subthalamic nucleus , neuroscience , white matter , tractography , diffusion mri , dystonia , computer science , medicine , physical medicine and rehabilitation , parkinson's disease , psychology , magnetic resonance imaging , radiology , disease , pathology
Abstract Deep brain stimulation (DBS) is an effective surgical treatment for movement disorders. Although stimulation sites for movement disorders such as Parkinson's disease are established, the therapeutic mechanisms of DBS remain controversial. Recent research suggests that specific white‐matter tract and circuit activation mediates symptom relief. To investigate these questions, we have developed a patient‐specific open‐source software pipeline called ‘DBSproc’ for (1) localizing DBS electrodes and contacts from postoperative CT images, (2) processing structural and diffusion MRI data, (3) registering all images to a common space, (4) estimating DBS activation volume from patient‐specific voltage and impedance, and (5) understanding the DBS contact‐brain connectivity through probabilistic tractography. In this paper, we explain our methodology and provide validation with anatomical and tractographic data. This method can be used to help investigate mechanisms of action of DBS, inform surgical and clinical assessments, and define new therapeutic targets. Hum Brain Mapp 37:422–433, 2016 . Published 2015. This article is a U.S. Government work and is in the public domain in the USA.