Open AccessRegion‐specific disturbed iron distribution in early idiopathic P arkinson's disease measured by quantitative susceptibility mapping
Author(s) -
He Naying,
Ling Huawei,
Ding Bei,
Huang Juan,
Zhang Yong,
Zhang Zhongping,
Liu Chunlei,
Chen Kemin,
Yan Fuhua
Publication year - 2015
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22928
Subject(s) - quantitative susceptibility mapping , putamen , grey matter , globus pallidus , caudate nucleus , substantia nigra , biomarker , parkinson's disease , red nucleus , dopaminergic , neurology , magnetic resonance imaging , medicine , chemistry , pathology , gastroenterology , basal ganglia , psychology , disease , neuroscience , central nervous system , nucleus , dopamine , white matter , radiology , biochemistry
In Parkinson's disease (PD), iron elevation in specific brain regions as well as selective loss of dopaminergic neurons is a major pathologic feature. A reliable quantitative measure of iron deposition is a potential biomarker for PD and may contribute to the investigation of iron‐mediated PD. The primary purpose of this study is to assess iron variations in multiple deep grey matter nuclei in early PD with a novel MRI technique, quantitative susceptibility mapping (QSM). The inter‐group differences of susceptibility and R2 * value in deep grey matter nuclei, namely head of caudate nucleus (CN), putamen (PUT), global pallidus (GP), substantia nigra (SN), and red nucleus (RN), and the correlations between regional iron deposition and the clinical features were explored in forty‐four early PD patients and 35 gender and age‐matched healthy controls. Susceptibility values were found to be elevated within bilateral SN and RN contralateral to the most affected limb in early PD compared with healthy controls (HCs). The finding of increased susceptibility in bilateral SN is consistent with work on a subgroup of patients at the earliest clinical detectable state (Hoehn and Yahr [1967]: Neurology 17:427–442; Stage I). However, increased R2 * values were only seen within SN contralateral to the most affected limb in the PD group when compared with controls. Furthermore, bilateral SN magnetic susceptibility positively correlated with disease duration and UPDRS‐III scores in early PD. This finding supports the potential value of QSM as a non‐invasive quantitative biomarker of early PD. Hum Brain Mapp 36:4407–4420, 2015 . © 2015 Wiley Periodicals, Inc .