z-logo
open-access-imgOpen Access
Detection of Alzheimer's disease signature in MR images seven years before conversion to dementia: Toward an early individual prognosis
Author(s) -
Coupé Pierrick,
Fonov Vladimir S.,
Bernard Charlotte,
Zandifar Azar,
Eskildsen Simon F.,
Helmer Catherine,
Manjón José V.,
Amieva Hélène,
Dartigues JeanFrançois,
Allard Michèle,
Catheline Gwenaelle,
Collins D. Louis
Publication year - 2015
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22926
Subject(s) - dementia , cohort , hippocampal formation , biomarker , grading (engineering) , medicine , oncology , imaging biomarker , alzheimer's disease , neuroimaging , alzheimer's disease neuroimaging initiative , receiver operating characteristic , neurodegeneration , disease , magnetic resonance imaging , neuroscience , pathology , psychology , radiology , psychiatry , biology , ecology , biochemistry
Finding very early biomarkers of Alzheimer's Disease (AD) to aid in individual prognosis is of major interest to accelerate the development of new therapies. Among the potential biomarkers, neurodegeneration measurements from MRI are considered as good candidates but have so far not been effective at the early stages of the pathology. Our objective is to investigate the efficiency of a new MR‐based hippocampal grading score to detect incident dementia in cognitively intact patients. This new score is based on a pattern recognition strategy, providing a grading measure that reflects the similarity of the anatomical patterns of the subject under study with dataset composed of healthy subjects and patients with AD. Hippocampal grading was evaluated on subjects from the Three‐City cohort, with a followup period of 12 years. Experiments demonstrate that hippocampal grading yields prediction accuracy up to 72.5% ( P  < 0.0001) 7 years before conversion to AD, better than both hippocampal volume (58.1%, P  = 0.04) and MMSE score (56.9%, P  = 0.08). The area under the ROC curve (AUC) supports the efficiency of imaging biomarkers with a gain of 8.4 percentage points for hippocampal grade (73.0%) over hippocampal volume (64.6%). Adaptation of the proposed framework to clinical score estimation is also presented. Compared with previous studies investigating new biomarkers for AD prediction over much shorter periods, the very long followup of the Three‐City cohort demonstrates the important clinical potential of the proposed imaging biomarker. The high accuracy obtained with this new imaging biomarker paves the way for computer‐based prognostic aides to help the clinician identify cognitively intact subjects that are at high risk to develop AD. Hum Brain Mapp 36:4758–4770, 2015 . © 2015 Wiley Periodicals, Inc .

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here