Open AccessThe trajectory of disturbed resting‐state cerebral function in Parkinson's disease at different Hoehn and Yahr stages
Author(s) -
Luo ChunYan,
Guo XiaoYan,
Song Wei,
Chen Qin,
Yang Jing,
Gong QiYong,
Shang HuiFang
Publication year - 2015
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22831
Subject(s) - posterior cingulate , default mode network , resting state fmri , neuroscience , functional connectivity , parkinson's disease , stage (stratigraphy) , cardiology , voxel , cortex (anatomy) , psychology , medicine , disease , biology , radiology , paleontology
Objective We aim to investigate the disturbance of neural network associated with the different clinical stages of Parkinson's disease (PD). Method We recruited 80 patients at different H&Y stages of PD (28 at H&Y stage I, 28 at H&Y stage II, 24 at H&Y stage III) and 30 normal controls. All participants underwent resting‐state fMRI scans on a 3‐T MR system. The amplitude of low‐frequency fluctuation (ALFF) of blood oxygen level‐dependent signals was used to characterize regional cerebral function. Functional integration across the brain regions was evaluated by a seed voxel correlation approach. Results PD patients had decreased regional activities in left occipital and lingual regions; these regions show decreased functional connection pattern with temporal regions, which is deteriorating as H&Y stage ascending. In addition, PD patients, especially those at stage II, exhibit increased regional activity in the posterior regions of default mode network (DMN), increased anticorrelation between posterior cingulate cortex (PCC) and cortical regions outside DMN, and higher temporal coherence within DMN. Those indicate more highly functioned DMN in PD patients at stage II. Conclusions Our study demonstrated the trajectories of resting‐state cerebral function disturbance in PD patients at different H&Y stages. Impairment in functional integration of occipital‐temporal cortex might be a promising measurement to evaluate and potentially track functional substrates of disease evolution of PD. Hum Brain Mapp 36:3104–3116, 2015 . © 2015 Wiley Periodicals, Inc.