Open AccessConnectivity of the subthalamic nucleus and globus pallidus pars interna to regions within the speech network: A meta‐analytic connectivity study
Author(s) -
Manes Jordan L.,
Parkinson Amy L.,
Larson Charles R.,
Greenlee Jeremy D.,
Eickhoff Simon B.,
Corcos Daniel M.,
Robin Donald A.
Publication year - 2014
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22417
Subject(s) - neuroscience , subthalamic nucleus , supplementary motor area , globus pallidus , basal ganglia , insula , psychology , coactivation , putamen , premotor cortex , motor cortex , brain mapping , functional magnetic resonance imaging , biology , deep brain stimulation , anatomy , parkinson's disease , medicine , electromyography , central nervous system , dorsum , disease , pathology , stimulation
Cortico‐basal ganglia connections are involved in a range of behaviors within motor, cognitive, and emotional domains; however, the whole‐brain functional connections of individual nuclei are poorly understood in humans. The first aim of this study was to characterize and compare the connectivity of the subthalamic nucleus (STN) and globus pallidus pars interna (GPi) using meta‐analytic connectivity modeling. Structure‐based activation likelihood estimation meta‐analyses were performed for STN and GPi seeds using archived functional imaging coordinates from the BrainMap database. Both regions coactivated with caudate, putamen, thalamus, STN, GPi, and GPe, SMA, IFG, and insula. Contrast analyses also revealed coactivation differences within SMA, IFG, insula, and premotor cortex. The second aim of this study was to examine the degree of overlap between the connectivity maps derived for STN and GPi and a functional activation map representing the speech network. To do this, we examined the intersection of coactivation maps and their respective contrasts (STN > GPi and GPi > STN) with a coordinate‐based meta‐analysis of speech function. In conjunction with the speech map, both STN and GPi coactivation maps revealed overlap in the anterior insula with GPi map additionally showing overlap in the supplementary motor area (SMA). Among cortical regions activated by speech tasks, STN was found to have stronger connectivity than GPi with regions involved in cognitive linguistic processes (pre‐SMA, dorsal anterior insula, and inferior frontal gyrus), while GPi demonstrated stronger connectivity to regions involved in motor speech processes (middle insula, SMA, and premotor cortex). Hum Brain Mapp 35:3499–3516, 2014 . © 2013 Wiley Periodicals, Inc .