Open AccessReconstruction of the human cerebral cortex robust to white matter lesions: Method and validation
Author(s) -
Shiee Navid,
Bazin PierreLouis,
Cuzzocreo Jennifer L.,
Ye Chuyang,
Kishore Bhaskar,
Carass Aaron,
Calabresi Peter A.,
Reich Daniel S.,
Prince Jerry L.,
Pham Dzung L.
Publication year - 2014
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22409
Subject(s) - white matter , neuroscience , cortex (anatomy) , multiple sclerosis , cerebral cortex , atrophy , magnetic resonance imaging , computer science , medicine , psychology , pathology , radiology , psychiatry
Cortical atrophy has been reported in a number of diseases, such as multiple sclerosis and Alzheimer's disease, that are also associated with white matter (WM) lesions. However, most cortical reconstruction techniques do not account for these pathologies, thereby requiring additional processing to correct for the effect of WM lesions. In this work, we introduce CRUISE + , an automated process for cortical reconstruction from magnetic resonance brain images with WM lesions. The process extends previously well validated methods to allow for multichannel input images and to accommodate for the presence of WM lesions. We provide new validation data and tools for measuring the accuracy of cortical reconstruction methods on healthy brains as well as brains with multiple sclerosis lesions. Using this data, we validate the accuracy of CRUISE + and compare it to another state‐of‐the‐art cortical reconstruction tool. Our results demonstrate that CRUISE + has superior performance in the cortical regions near WM lesions, and similar performance in other regions. Hum Brain Mapp 35:3385–3401, 2014 . © 2013 Wiley Periodicals, Inc .