Open AccessDopamine‐agonists and impulsivity in Parkinson's disease: Impulsive choices vs. impulsive actions
Author(s) -
Antonelli Francesca,
Ko Ji Hyun,
Miyasaki Janis,
Lang Anthony E.,
Houle Sylvain,
Valzania Franco,
Ray Nicola J.,
Strafella Antonio P.
Publication year - 2014
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22344
Subject(s) - pramipexole , impulsivity , prefrontal cortex , psychology , neuroscience , dopamine , posterior cingulate , parkinson's disease , anterior cingulate cortex , cingulate cortex , ventral striatum , striatum , functional magnetic resonance imaging , cognition , medicine , psychiatry , disease , central nervous system
The control of impulse behavior is a multidimensional concept subdivided into separate subcomponents, which are thought to represent different underlying mechanisms due to either disinhibitory processes or poor decision‐making. In patients with Parkinson's disease (PD), dopamine‐agonist (DA) therapy has been associated with increased impulsive behavior. However, the relationship among these different components in the disease and the role of DA is not well understood. In this imaging study, we investigated in PD patients the effects of DA medication on patterns of brain activation during tasks testing impulsive choices and actions. Following overnight withdrawal of antiparkinsonian medication, PD patients were studied with a H 2 (15) O PET before and after administration of DA (1 mg of pramipexole), while they were performing the delay discounting task (DDT) and the GoNoGo Task (GNG). We observed that pramipexole augmented impulsivity during DDT, depending on reward magnitude and activated the medial prefrontal cortex and posterior cingulate cortex and deactivated ventral striatum. In contrast, the effect of pramipexole during the GNG task was not significant on behavioral performance and involved different areas (i.e., lateral prefrontal cortex). A voxel‐based correlation analysis revealed a significant negative correlation between the discounting value (k) and the activation of medial prefrontal cortex and posterior cingulate suggesting that more impulsive patients had less activation in those cortical areas. Here we report how these different subcomponents of inhibition/impulsivity are differentially sensitive to DA treatment with pramipexole influencing mainly the neural network underlying impulsive choices but not impulsive action. Hum Brain Mapp 35:2499–2506, 2014 . © 2013 Wiley Periodicals, Inc.