Open AccessReliability of neuroanatomical measurements in a multisite longitudinal study of youth at risk for psychosis
Author(s) -
Can Tyrone D.,
Sun Frank,
McEwen Sarah Jacobson,
Papademetris Xenophon,
He George,
van Erp Theo G.M.,
Jacobson Aron,
Bearden Carrie E.,
Walker Elaine,
Hu Xiaoping,
Zhou Lei,
Seidman Larry J.,
Thermenos Heidi W.,
Cornblatt Barbara,
Olvet Doreen M.,
Perkins Diana,
Belger Aysenil,
Cadenhead Kristin,
Tsuang Ming,
Mirzakhanian Heline,
Addington Jean,
Frayne Richard,
Woods Scott W.,
McGlashan Thomas H.,
Constable R. Todd,
Qiu Maolin,
Mathalon Daniel H.,
Thompson Paul,
Toga Arthur W.
Publication year - 2014
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22338
Subject(s) - neuroimaging , voxel , psychology , scanner , reliability (semiconductor) , prodrome , statistical power , psychosis , neuroscience , artificial intelligence , computer science , statistics , mathematics , power (physics) , physics , quantum mechanics , psychiatry
Multisite longitudinal neuroimaging designs are used to identify differential brain structural change associated with onset or progression of disease. The reliability of neuroanatomical measurements over time and across sites is a crucial aspect of power in such studies. Prior work has found that while within‐site reliabilities of neuroanatomical measurements are excellent, between‐site reliability is generally more modest. Factors that may increase between‐site reliability include standardization of scanner platform and sequence parameters and correction for between‐scanner variations in gradient nonlinearities. Factors that may improve both between‐ and within‐site reliability include use of registration algorithms that account for individual differences in cortical patterning and shape. In this study 8 healthy volunteers were scanned twice on successive days at 8 sites participating in the North American Prodrome Longitudinal Study (NAPLS). All sites employed 3 Tesla scanners and standardized acquisition parameters. Site accounted for 2 to 30% of the total variance in neuroanatomical measurements. However, site‐related variations were trivial (<1%) among sites using the same scanner model and 12‐channel coil or when correcting for between‐scanner differences in gradient nonlinearity and scaling. Adjusting for individual differences in sulcal‐gyral geometries yielded measurements with greater reliabilities than those obtained using an automated approach. Neuroimaging can be performed across multiple sites at the same level of reliability as at a single site, achieving within‐ and between‐site reliabilities of 0.95 or greater for gray matter density in the majority of voxels in the prefrontal and temporal cortical surfaces as well as for the volumes of most subcortical structures. Hum Brain Mapp 35:2424–2434, 2014 . © 2013 Wiley Periodicals, Inc .