Open AccessImaging the interaction: Epileptic discharges, working memory, and behavior
Author(s) -
Chaudhary Umair J.,
Centeno Maria,
Carmichael David W.,
Vollmar Christian,
Rodionov Roman,
Bonelli Silvia,
Stretton Jason,
Pressler Ronit,
Eriksson Sofia H.,
Sisodiya Sanjay,
Friston Karl,
Duncan John S.,
Lemieux Louis,
Koepp Matthias
Publication year - 2013
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22115
Subject(s) - precuneus , working memory , neuroscience , psychology , ictal , frontal lobe , parietal lobe , hum , cognition , electroencephalography , art , performance art , art history
Interictal generalized epileptiform discharges may impair cognition. We used simultaneous video‐electroencephalography and functional imaging to quantify changes, induced by epileptiform discharges, in the task‐related activations during a spatial working‐memory paradigm. The number of epileptiform discharges increased during the task with its level of complexity, but were not significantly associated with wrong responses during the task. We observed hemodynamic responses in working‐memory related frontal‐lobe‐network, motor‐cortex, precuneus, and parietal lobes in the absence of epileptiform discharges. In the presence of epileptiform discharges during the task, task‐related hemodynamic changes were seen only in motor‐cortex, precuneus, and parietal lobes. These findings suggest that generalized epileptiform discharges during a high demanding working memory task may change the working memory‐related hemodynamic responses in frontal‐lobe‐network. Hum Brain Mapp 34:2910–2917, 2013. © 2012 Wiley Periodicals, Inc.