Open AccessRole of medial cortical networks for anticipatory processing in obsessive‐compulsive disorder
Author(s) -
Ciesielski Kristina T.,
Rauch Scott L.,
Ahlfors Seppo P.,
Vangel Mark E.,
Wilhelm Sabine,
Rosen Bruce R.,
Hämäläinen Matti S.
Publication year - 2012
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.21341
Subject(s) - neuroscience , psychology , anterior cingulate cortex , anticipation (artificial intelligence) , obsessive compulsive , magnetoencephalography , posterior cingulate , cortex (anatomy) , fusiform gyrus , functional magnetic resonance imaging , cognition , electroencephalography , psychiatry , artificial intelligence , computer science
Recurrent anticipation of ominous events is central to obsessions, the core symptom of obsessive‐compulsive disorder (OCD), yet the neural basis of intrinsic anticipatory processing in OCD is unknown. We studied nonmedicated adults with OCD and case matched healthy controls in a visual‐spatial working memory task with distractor. Magnetoencephalography was used to examine the medial cortex activity during anticipation of to‐be‐inhibited distractors and to‐be‐facilitated retrieval stimuli. In OCD anticipatory activation to distractors was abnormally reduced within the posterior cingulate and fusiform gyrus compared to prominent activation in controls. Conversely, OCD subjects displayed significantly increased activation to retrieval stimuli within the anterior cingulate and supplementary motor cortex. This previously unreported discordant pattern of medial anticipatory activation in OCD was accompanied by normal performance accuracy. While increased anterior cortex activation in OCD is commonly viewed as failure of inhibition, the current pattern of data implicates the operation of an anterior compensatory mechanism amending the posterior medial self‐regulatory networks disrupted in OCD. Hum Brain Mapp 33:2125–2134, 2012. © 2011 Wiley Periodicals, Inc.