Open AccessFrontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness
Author(s) -
Bastin Christine,
Feyers Dorothée,
Souchay Céline,
Guillaume Bénédicte,
Pepin JeanLouis,
Lemaire Christian,
Degueldre Christian,
Collette Fabienne,
Salmon Eric
Publication year - 2012
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.21282
Subject(s) - frontotemporal dementia , posterior cingulate , psychology , neuroscience , dementia , cognitive impairment , frontal lobe , memory impairment , cognitive psychology , medicine , cognition , disease
Abstract Although memory dysfunction is not a prominent feature of the behavioral variant of frontotemporal dementia (bv‐FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability to consciously retrieve own encoding of the context of events (autonoetic consciousness) and the ability to monitor memory performance using feeling‐of‐knowing (FOK) in bv‐FTD. Analyses of the patients' cerebral metabolism (FDG‐PET) allowed an examination of whether impaired episodic memory in bv‐FTD is associated with the frontal dysfunction characteristic of the pathology or a dysfunction of memory‐specific regions pertaining to Papez's circuit. Data were obtained from eight bv‐FTD patients and 26 healthy controls. Autonoetic consciousness was evaluated by Remember responses during the recognition memory phase of the FOK experiment. As a group, bv‐FTD patients demonstrated a decline in autonoetic consciousness and FOK accuracy at the chance level. While memory monitoring was impaired in most (seven) patients, four bv‐FTD participants had individual impairment of autonoetic consciousness. They specifically showed reduced metabolism in the anterior medial prefrontal cortex, the left dorsolateral prefrontal cortex (near the superior frontal sulcus), parietal regions, and the posterior cingulate cortex. These findings were tentatively interpreted by considering the role of the metabolically impaired brain regions in self‐referential processes, suggesting that the bv‐FTD patients' problem consciously retrieving episodic memories may stem at least partly from deficient access to and maintenance/use of information about the self. Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.