Open AccessInvolvement of glutamate in rest‐stimulus interaction between perigenual and supragenual anterior cingulate cortex: A combined fMRI‐MRS study
Author(s) -
Duncan Niall W.,
Enzi Björn,
Wiebking Christine,
Northoff Georg
Publication year - 2011
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.21179
Subject(s) - anterior cingulate cortex , stimulus (psychology) , neuroscience , functional connectivity , psychology , resting state fmri , brain activity and meditation , default mode network , glutamate receptor , medicine , cognitive psychology , cognition , electroencephalography , receptor
The brain shows a high degree of activity at rest. The significance of this activity has come increasingly into focus. At present, however, the interaction between this activity and stimulus‐induced activity is not well defined. The interaction between a task‐negative (perigenual anterior cingulate cortex, pgACC) and task‐positive (supragenual anterior cingulate cortex, sgACC) region during a simple task was thus investigated using a combination of fMRI and MRS. Negative BOLD responses in the pgACC were found to show a unidirectional effective connectivity with task‐induced positive BOLD responses in the sgACC. This connectivity was shown to be related specifically with glutamate levels in the pgACC. These results demonstrate an interaction between deactivation from resting‐state and resting‐state glutamate levels in a task‐negative region (pgACC), and task‐induced activity in a task‐positive region (sgACC). This provides insight into the neuronal and biochemical mechanisms by means of which the resting state activity of the brain potentially impacts upon subsequent stimulus‐induced activity. Hum Brain Mapp, 2011. © 2011 Wiley Periodicals, Inc.