Open AccessNoninvasive optical measures of CBV, StO 2 , CBF index, and rCMRO 2 in human premature neonates' brains in the first six weeks of life
Author(s) -
RocheLabarbe Nadège,
Carp Stefan A.,
Surova Andrea,
Patel Megha,
Boas David A.,
Grant P. Ellen,
Franceschini Maria Angela
Publication year - 2010
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.20868
Subject(s) - cerebral blood flow , medicine , hemodynamics , cerebral blood volume , gestational age , oxygenation , cardiology , anesthesia , pregnancy , biology , genetics
With the causes of perinatal brain injuries still unclear and the probable role of hemodynamic instability in their etiology, bedside monitoring of neonatal cerebral hemodynamics with standard values as a function of age are needed. In this study, we combined quantitative frequency domain near infrared spectroscopy (FD‐NIRS) measures of cerebral tissue oxygenation (StO 2 ) and cerebral blood volume (CBV) with diffusion correlation spectroscopy (DCS) measures of a cerebral blood flow index (CBF ix ) to test the validity of the CBV‐CBF relationship in premature neonates and to estimate cerebral metabolic rate of oxygen (rCMRO 2 ) with or without the CBF ix measurement. We measured 11 premature neonates (28–34 weeks gestational age) without known neurological issues, once a week from one to six weeks of age. In nine patients, cerebral blood velocities from the middle cerebral artery were collected by transcranial Doppler (TCD) and compared with DCS values. Results show a steady decrease in StO 2 during the first six weeks of life while CBV remains stable, and a steady increase in CBF ix . rCMRO 2 estimated from FD‐NIRS remains constant but shows wide interindividual variability. rCMRO 2 calculated from FD‐NIRS and DCS combined increased by 40% during the first six weeks of life with reduced interindividual variability. TCD and DCS values are positively correlated. In conclusion, FD‐NIRS combined with DCS offers a safe and quantitative bedside method to assess CBV, StO 2 , CBF, and rCMRO 2 in the premature brain, facilitating individual follow‐up and comparison among patients. A stable CBV‐CBF relationship may not be valid for premature neonates. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.