Open AccessReproducibility of TMS—Evoked EEG responses
Author(s) -
Lioumis Pantelis,
Kičić Dubravko,
Savolainen Petri,
Mäkelä Jyrki P.,
Kähkönen Seppo
Publication year - 2009
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.20608
Subject(s) - transcranial magnetic stimulation , electroencephalography , reproducibility , neuroscience , psychology , stimulation , audiology , motor cortex , magnetoencephalography , medicine , chemistry , chromatography
Abstract Navigated transcranial magnetic stimulation combined with electroencephalography (nTMS‐EEG), allows noninvasive studies of cortical excitability and connectivity in humans. We investigated the reproducibility of nTMS‐EEG in seven healthy subjects by repeating left motor and prefrontal cortical stimulation with a 1‐week interval. TMS was applied at three intensities: 90, 100, and 110% of subjects' motor threshold (MT). The TMS‐compatible neuronavigation system guaranteed precise repositioning of the stimulation coil. The responses were recorded by a 60‐channel whole head TMS‐compatible EEG amplifier. A high overall reproducibility ( r > 0.80) was evident in nTMS‐EEG responses over both hemispheres for both motor and prefrontal cortical stimulation. The results suggest that nTMS‐EEG is a reliable tool for studies investigating cortical excitability changes in the test‐retest designs. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.