Open AccessModel‐free group analysis shows altered BOLD FMRI networks in dementia
Author(s) -
Rombouts Serge A.R.B.,
Damoiseaux Jessica S.,
Goekoop Rutger,
Barkhof Frederik,
Scheltens Philip,
Smith Stephen M.,
Beckmann Christian F.
Publication year - 2009
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.20505
Subject(s) - psychology , neuroimaging , independent component analysis , dementia , group analysis , default mode network , cognition , neuroscience , frontotemporal dementia , pattern recognition (psychology) , artificial intelligence , cognitive psychology , computer science , medicine , disease , social psychology
FMRI research in Alzheimer's disease (AD) and mild cognitive impairment (MCI) typically is aimed at determining regional changes in brain function, most commonly by creating a model of the expected BOLD‐response and estimating its magnitude using a general linear model (GLM) analysis. This crucially depends on the suitability of the temporal assumptions of the model and on assumptions about normality of group distributions. Exploratory data analysis techniques such as independent component analysis (ICA) do not depend on these assumptions and are able to detect unknown, yet structured spatiotemporal processes in neuroimaging data. Tensorial probabilistic ICA (T‐PICA) is a model free technique that can be used for analyzing multiple subjects and groups, extracting signals of interest (components) in the spatial, temporal, and also subject domain of FMRI data. We applied T‐PICA and model‐based GLM to study FMRI signal during face encoding in 18 AD, 28 MCI patients, and 41 healthy elderly controls. T‐PICA showed activation in regions associated with motor, visual, and cognitive processing, and deactivation in the default mode network. Six networks showed a significantly decreased response in patients. For two networks the T‐PICA technique was significantly more sensitive to detect group differences than the standard model‐based technique. We conclude that T‐PICA is a promising tool to identify and detect differences in (de)activated brain networks in elderly controls and dementia patients. The technique is more sensitive than the commonly applied model‐based method. Consistent with other research, we show that networks of activation and deactivation show decreased reactivity in dementia. Hum Brain Mapp 2009. © 2007 Wiley‐Liss, Inc.