Open AccessFunction of striatum beyond inhibition and execution of motor responses
Author(s) -
Vink Matthijs,
Kahn René S.,
Raemaekers Mathijs,
van den Heuvel Martijn,
Boersma Maria,
Ramsey Nick F.
Publication year - 2005
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.20111
Subject(s) - striatum , functional magnetic resonance imaging , neuroscience , psychology , ventral striatum , motor control , hum , inhibitory control , motor function , motor system , supplementary motor area , inhibitory postsynaptic potential , physical medicine and rehabilitation , medicine , cognition , dopamine , art , performance art , art history
We used functional magnetic resonance imaging (fMRI) to study the role of the striatum in inhibitory motor control. Subjects had to refrain from responding to designated items (STOP trials) within a similar series of motor stimuli. Striatal activation was increased significantly compared to that when responding to all targets within a series of motor stimuli, indicating that the striatum is more active when inhibitory motor control over responses is required. The likelihood of a STOP trial was varied parametrically by varying the number of GO trials before a STOP trial. We could thus measure the effect of expecting a STOP trial on the fMRI response in the striatum. We show for the first time in humans that the striatum becomes more active when the likelihood of inhibiting a planned motor response increases. Our findings suggest that the striatum is critically involved in inhibitory motor control, most likely by controlling the execution of planned motor responses. Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.