Open AccessEffect of prior cognitive state on resting state networks measured with functional connectivity
Author(s) -
Waites Anthony B.,
Stanislavsky Alexandra,
Abbott David F.,
Jackson Graeme D.
Publication year - 2005
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.20069
Subject(s) - resting state fmri , posterior cingulate , cognition , functional connectivity , dynamic functional connectivity , rest (music) , neuroscience , voxel , cortex (anatomy) , brain mapping , psychology , brain activity and meditation , task (project management) , default mode network , cognitive psychology , computer science , electroencephalography , artificial intelligence , medicine , cardiology , management , economics
To address the extent to which functional connectivity measures an absolute brain state, we observed the effect of prior performance of a language task on resting‐state networks in regions associated with language. Six subjects were imaged during rest before and after a block‐design language task. Connectivity maps were generated for each of four language regions (identified from analysis of the language activation portion of the study) in each subject for both rest periods. Conjunction analysis demonstrated distinct networks of voxels for each seed region, indicating separate functional subnetworks associated with the different regions. In a comparison of rest before and after the activation task widespread and significant changes were observed in all individuals, suggesting that the measured resting state network reflects a dynamic image of the current brain state. At the group level, an extended network was observed that was largely persistent over time. Even at the group level an increase in connectivity was observed between left and right middle frontal gyri, and between posterior cingulate cortex and medial frontal cortex in the rest after the language task. These results suggest that functional connectivity may be a powerful measure of cognitive state, sensitive to differences between controls and patients together with the particular cognitive processing occurring during the rest state. Hum. Brain Mapping 24:59–68, 2005. © 2004 Wiley‐Liss, Inc.