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Scopolamine‐induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers
Author(s) -
Barker Andrew,
Jones Roy,
Simpson Pauline,
Wesnes Keith
Publication year - 1995
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.930101211
Subject(s) - cognitive decline , scopolamine , cognition , psychology , cognitive impairment , cognitive test , medicine , audiology , gerontology , dementia , psychiatry , anesthesia , disease
There are theoretical grounds for believing that scopolamine‐induced cognitive deficit may be predictive of future cognitive decline. In the present study, 22 healthy elderly volunteers were reassessed 3 years after a scopolamine challenge. Although there was little overall change in mean cognitive test scores over time, in two out of 10 tests scopolamine‐induced decrement was related to subsequent decline.