Premium
Cerebral blood flow changes in normal aging: Spect measurements
Author(s) -
Swartz J. Randolph,
Lesser Ira M.,
Boone Kyle B.,
Miller Bruce L.,
Mena Ismael
Publication year - 1995
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.930100603
Subject(s) - cerebral blood flow , single photon emission computed tomography , perfusion , cardiology , occipital lobe , frontal lobe , medicine , emission computed tomography , nuclear medicine , psychology , radiology , psychiatry
Global and regional cerebral blood flow (CBF) were evaluated with single photon emission computerized tomography (SPECT) utilizing both 133 Xenon ( 133 Xe) (47 subjects, 47–82 years old) and 99 Tc‐hexamethylpropyleneamine oxime ( 99 Tc‐HMPAO) (27 subjects, 47–80 years old). The 133 Xe results showed: among total subjects, no age‐related decline in global CBF, but a significant regional decline in the occipital lobe ( p < 0.05); among men, significant age‐related declines in global, frontal, temporal, occipital and right hemisphere CBF (all p < 0.05); among women, no age‐related decline in global or regional CBF. The 99 Tc‐HMPAO results showed no age‐related decline in either global or regional perfusion among total subjects, men or women. These results suggest that age‐related global and regional (including frontal lobe) CBF declines do not occur in healthy control subjects after the age of 45 years. However, gender differences in age‐related CBF changes warrant further study.