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Apolipoprotein e genotype and late paraphrenia
Author(s) -
Howard Robert,
Dennehey John,
Lovestone Simon,
Birkett Joseph,
Sham Pak,
Powell John,
Castle David,
Murray Robin,
Levy Raymond
Publication year - 1995
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.930100210
Subject(s) - apolipoprotein e , genotype , dementia , allele , disease , alzheimer's disease , degenerative disease , medicine , cognitive impairment , allele frequency , psychology , schizophrenia (object oriented programming) , psychiatry , gastroenterology , genetics , biology , gene
Patients with late paraphrenia or late onset schizophrenia frequently have associated cognitive impairment which may in some cases progress to a recognized dementia. The frequency of the apoE ϵ4 allele is high in individuals who develop Alzheimer's disease. Twenty‐three patients with late paraphrenia were genotyped for ApoE. The frequency of the ϵ4 allele was comparable with that found in a large group of centenarians, but lower than previously reported from populations of normal controls and Alzheimer's disease patients. Two out of three male patients tested had the rare ϵ2/ϵ2 genotype, which was not found in any of the females.