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White matter hyperintensities in healthy older adults: A longitudinal study
Author(s) -
Wohl Marcy A.,
Mehringer C. Mark,
Lesser Ira M.,
Boone Kyle B.,
Miller Bruce L.
Publication year - 1994
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.930090403
Subject(s) - hyperintensity , longitudinal study , magnetic resonance imaging , medicine , white matter , cardiovascular health , psychology , gerontology , cardiology , pathology , radiology , disease
A 3‐year longitudinal study was conducted using magnetic resonance imaging (MRI) to determine the progression of white matter hyperintensities (WMH) and ventricle‐to‐brain ratio (VBR) in 16 healthy older adults. We found that, as a group, the subjects' WMH showed little progression over a 3‐year period, but their VBR significantly increased during that same period of time. This increase occurred in healthy older adults who did not develop serious medical problems during the course of the 3‐year study. In two of the subjects, with the largest increases in both WMH and VBR, there was a change in their health status.