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Single photon emission tomography in Alzheimer's disease. A longitudinal study of changes in relative regional cerebral blood flow
Author(s) -
Philpot Michael P.,
Costa Durval C.,
Burns Alistair,
Levy Raymond,
Ell Peter J.
Publication year - 1991
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.930061103
Subject(s) - cerebral blood flow , single photon emission computed tomography , positron emission tomography , emission computed tomography , alzheimer's disease , cardiology , neuropsychological test , laterality , medicine , frontal lobe , nuclear medicine , central nervous system disease , neuropsychology , lateralization of brain function , psychology , audiology , neuroscience , disease , cognition
Abstract Relative regional cerebral blood (rCBF) was measured in 10 patients fulfilling NINCDS‐ADRDA criteria for Alzheimer's disease using Tc‐99m‐HMPAO single photon emission tomography (SPET). In comparison with 11 age‐matched control subjects, relative rCBF was reduced in lateral and medial temporal areas. SPET was repeated after 12‐18 months. Relative rCBF fell significantly in the frontal and anterior and posterior parietal areas. Significant changes in left/right asymmetry were found in the frontal and posterior parietal areas suggestinga greater reduction in left hemisphere rCBF. There were few associations between relative rCBF and neuropsychological test performance.