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Platelet membrane fluidity, family history, severity and age of onset in Alzheimer's disease
Author(s) -
Eagger Sarah,
Hajimohammadreza Iradj,
Fletcher Keron,
Levy Raymond,
Brammer Michael
Publication year - 1990
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.930050608
Subject(s) - membrane fluidity , family history , alzheimer's disease , platelet , disease , medicine , degenerative disease , psychology , endocrinology , membrane , biology , biochemistry
Platelet membrane fluidity values were assessed in three groups of subjects: (1) 15 Alzheimer's disease patients with a first‐degree family history of the disorder; (2) 16 Alzheimer's disease patients with no family history of the disorder; (3) 22 healthy control subjects. The distributions of platelet membrane fluidity changes were found to be the same in both Alzheimer disease groups, but none of the controls had raised platelet membrane fluidity Severity of Alzheimer's disease as measured by Mini‐Mental State and Cambridge Cognitive Index scores correlated with platelet membrane fluidity values significantly for the non‐family history group but not for the family history group. There was no apparent association between raised platelet membrane fluidity and age of onset of Alzheimer's disease. There was no evidence to indicate that raised platelet membrane fluidity is a peripheral marker for familial Alzheimer's disease.