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Selective loss of serotonin recognition sites in the parietal cortex in Alzheimer's disease
Author(s) -
Procter Andrew W.,
Middlemiss Derek N.,
Bowen David M.
Publication year - 1988
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.930030106
Subject(s) - posterior parietal cortex , serotonin , alzheimer's disease , cortex (anatomy) , ketanserin , cerebral cortex , temporal cortex , neuroscience , ageing , psychology , degenerative disease , parietal lobe , medicine , disease , endocrinology , central nervous system disease , 5 ht receptor , receptor
Numbers of serotonin (5‐HT) recognition sites of total 5‐HT 1 , 5‐HT 1A and 5‐HT 2 subtypes have been measured in frontal, temporal and parietal cortex from human brain postmortem, using binding of [ 3 H] 5‐hydroxytryptamine (5‐HT), [ 3 H] 8‐hydroxy‐2‐(di‐n‐propylamino) tetralin and [ 3 H] ketanserin, respectively. A comparison has been made between 11 patients with Alzheimer's disease (AD) and 20 matched controls. Significant disease‐related differences were observed only in the parietal cortex for total 5‐HT 1 and 5‐HT 2 recognition sites. Age‐related decrease in numbers of 5‐HT 2 recognition sites was seen in the controls, whereas an age‐related increase in the numbers of the same site was seen in AD patients. These changes are discussed in relation to disease severity and cortical nerve cell loss in ageing and AD.