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Depression in vascular dementia
Author(s) -
Naarding Paul,
de Koning Inge,
van Kooten Fop,
Dippel Diederik W. J.,
Janzing Joost G. E.,
van der Mast Rose C.,
Koudstaal Peter J.
Publication year - 2003
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.831
Subject(s) - psychomotor learning , dementia , depression (economics) , mood , psychology , vascular dementia , psychomotor retardation , cognition , psychiatry , stroke (engine) , psychomotor agitation , major depressive disorder , clinical psychology , medicine , pathology , disease , mechanical engineering , alternative medicine , engineering , economics , macroeconomics
Abstract Objective To study the presence of different dimensions of depression in subjects with vascular dementia. Background After a stroke, cognitive, affective and behavioural disturbances are common. It has been suggested that the nature of affective symptomatology can help to differentiate organic from psychological depression. Methods Cognitive and affective symptoms were assessed in 78 stroke patients and a principal component analysis was performed on these symptoms. Also, a discriminant analysis was carried out to establish the contribution of different symptoms on the diagnosis ‘depressive disorder’ and ‘dementia’. Results (1) Principal component analysis revealed three distinct sub‐syndromes: one with predominantly mood symptoms, one with essentially psychomotor symptoms, and one with vegetative symptoms; (2) mood, psychomotor and vegetative symptoms were all independently and strongly related to a diagnosis of major depressive disorder according to DSM‐III‐R criteria; (3) the psychomotor factor was also firmly associated with dementia; and (4) discriminant analysis gave further support for our conclusion that some of the depressive features, in particular the psychomotor factor, are at least partly related to the organic brain damage from stroke. Conclusion The results indicate that different dimensions of depression could be discerned in a group of stroke patients and that the symptom profile of depression in these patients can be affected by the presence of dementia. Copyright © 2003 John Wiley & Sons, Ltd.