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Apolipoprotein E ε4 allele is not associated with the cognitive impairment in community‐dwelling normal elderly individuals
Author(s) -
Kim K. W.,
Youn J. C.,
Jhoo J. H.,
Lee D. Y.,
Lee K. U.,
Lee J. H.,
Woo J. I.
Publication year - 2002
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.664
Subject(s) - apolipoprotein e , allele , neuropsychology , gerontology , psychology , cognition , medicine , risk factor , neuropsychological test , cognitive decline , dementia , psychiatry , disease , genetics , biology , gene
Objectives The aim of this study was to examine whether the APOE ε4 allele also confers a risk for the cognitive impairment in normal aging. Methods We administered all the eight neuropsychological tests from the CERAD neuropsychological battery to the CVD‐free, community‐dwelling normal elderly individuals, and compared their performance by the occurrence of the APOE ε4 allele. Results Either the impact of APOE ε4 allele itself or its interaction terms with age and gender of the subjects did not influence the performance of the eight neuropsychological tests (ε p > 0.1 by ANCOVA). Conclusions The APOE ε4 allele is not a risk factor for the cognitive decline in normal elderly individuals regardless of age and gender. Copyright © 2002 John Wiley & Sons, Ltd.