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Mood in Parkinson's disease: From early‐ to late‐stage disease
Author(s) -
SantosGarcía Diego,
De Deus Fonticoba T.,
Cores Bartolome C.,
Valdés Aymerich L.,
Suárez Castro E.,
Aneiros Ángel,
Jesús Silvia,
Aguilar Miquel,
Pastor Pau,
Planellas Lluís,
Cosgaya Marina,
García Caldente J.,
Caballol Nuria,
Legarda Inés,
Hernández Vara J.,
Cabo Iria,
López Manzanares L.,
González Aramburu I.,
Ávila Rivera M. A.,
José Catalán M.,
Nogueira Víctor,
Puente Víctor,
García Moreno J. M.,
Borrué Carmen,
Solano Vila B.,
Álvarez Sauco M.,
Vela Lydia,
Escalante Sonia,
Cubo Esther,
Carrillo Padilla F.,
Martínez Castrillo J. C.,
Sánchez Alonso P.,
Alonso Losada M. G.,
López Ariztegui N.,
Gastón Itziar,
Kulisevsky Jaime,
Blázquez Estrada M.,
Seijo Manuel,
Rúiz Martínez J.,
Valero Caridad,
Kurtis Mónica,
de FábreguesBoixar Oriol,
González Ardura J.,
Prieto Jurczynska C.,
López Díaz L.,
McAfee Darrian,
Mir Pablo
Publication year - 2021
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.5461
Subject(s) - mood , beck depression inventory , quality of life (healthcare) , depression (economics) , parkinson's disease , psychology , cohort , medicine , disease , psychiatry , anxiety , economics , macroeconomics , psychotherapist
Background Although depression is known to be frequent in Parkinson's disease (PD), it is unclear how mood can change and/or impact on patient's quality of life (QoL) over time. Our aim was to analyze the frequency of depression, mood related factors and the contribution of mood to a patient's QoL perception in regard to disease duration. Methods PD patients recruited from the COPPADIS cohort from January 2016 to November 2017 were included in this cross‐sectional study. Three groups were defined: <5 years (Group A); from 5 to <10 years (Group B); ≥10 years (Group C). Analysis with well‐planned linear regression models was conducted to determine how different factors contribute to mood (Beck Depression Inventory‐II [BDI‐II] as dependent variable), to health‐related QoL (39‐item Parkinson's Disease Questionnaire [PDQ‐39SI] as dependent variable) and to global QoL (European Health Interview Survey – Quality of Life Eight‐Item Index [EUROHIS‐QOL8] as dependent variable). Results Six hundred and sixty‐three PD patients (62.6 ± 8.9 years old, 59.6% males) were included: Group A, 50.1% ( n = 332); Group B, 33.3% ( n = 221) and Group C, 16.6% ( n = 110). There were no differences between the three groups in terms of the frequency of depressive symptoms nor the frequency of depression type (major vs. minor vs. subthreshold) ( p = 0.729). However, the unique percent variance of PDQ‐39SI and EUROHIS‐QOL8 explained by BDI‐II total score was 2 (23.7%) and threefold (26.9%), respectively, in Group C compared to the other two groups. EUROHIS‐QOL8 total score provided the highest unique contribution to mood (16.8%). Conclusions Although depression‐type frequency does not appear to change over time in PD; the contribution of mood on QoL perception is greater in patients with longer disease duration.