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White matter lesions and temporal atrophy are associated with cognitive and neuropsychiatric symptoms in patients with hypertension and Alzheimer's disease
Author(s) -
GarcíaAlberca José María,
Mendoza Silvia,
Gris Esther,
Royo José Luis,
CruzGamero José Manuel,
GarcíaCasares Natalia
Publication year - 2020
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.5366
Subject(s) - hyperintensity , medicine , atrophy , neuroimaging , cognition , disease , alzheimer's disease , dementia , white matter , cognitive decline , magnetic resonance imaging , cardiology , pediatrics , psychiatry , radiology
Objectives An increasing evidence suggests hypertension (HTN) could be linked to cognitive impairment and incident Alzheimer's disease (AD). The precise mechanisms linking HTN and AD are not well‐known. The aim of this study was to assess the putative association between HTN and AD. Methods We assessed in patients with AD associations between HTN and demographic and clinical data, vascular risk factors, treatments, APOE genotypes, brain white matter hyperintensities (WMH), and medial temporal atrophy (MTA) in multivariate analysis of covariance. Results We studied 92 patients with AD (mean ± SD age: 72.12 ± 6.91; women: 66.30%). Patients with HTN had significantly worse cognitive and functional status and higher frequency and severity of neuropsychiatric symptoms ( P = .010). Magnetic resonance imaging analyzes showed significant increases in WMH ( P = .018) and in MTA ( P = .012) in patients with AD with HTN compared with those without HTN. Conclusions Neuroimaging burden (MTA and higher degree of severity of WMH) among patients with AD and HTN are associated with the impaired cognitive function and neuropsychiatric symptoms.