Premium
Prospective longitudinal evaluation of cytokines in mild cognitive impairment due to AD and Lewy body disease
Author(s) -
Thomas Alan J.,
Hamilton Calum A.,
Donaghy Paul C.,
MartinRuiz Carmen,
Morris Chris M.,
Barnett Nicola,
Olsen Kirsty,
Taylor JohnPaul,
O'Brien John T.
Publication year - 2020
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.5365
Subject(s) - proinflammatory cytokine , prospective cohort study , disease , medicine , alzheimer's disease , cytokine , cognition , cognitive decline , longitudinal study , lewy body , dementia with lewy bodies , inflammation , psychology , gastroenterology , dementia , psychiatry , pathology
Objectives We conducted a prospective longitudinal study of plasma cytokines during the Mild Cognitive Impairment (MCI) stage of Lewy body disease and Alzheimer's disease, hypothesizing that cytokine levels would decrease over time and that this would be correlated with decline in cognition. Methods Older (≥60) people with MCI were recruited from memory services in healthcare trusts in North East England, UK. MCI was diagnosed as due to Alzheimer's disease (MCI‐AD) or Lewy body disease (MCI‐LB). Baseline and repeat annual clinical and cognitive assessments were undertaken and plasma samples were obtained at the same time. Cytokine assays were performed on all samples using the Meso Scale Discovery V‐Plex Plus Proinflammatory Panel 1, which included IFNγ, IL‐1β, IL‐2, IL‐4, IL‐6, IL‐8, IL‐10, IL‐12p70, IL‐13 and TNFα. Results Fifty‐six patients (21 MCI‐AD, 35 MCI‐LB) completed prospective evaluations and provided samples up to 3 years after baseline. Six cytokines (IFNγ, IL‐1β, IL‐2, IL‐4, IL‐6 and IL‐10) showed highly significant ( P < .002) decreases over time. AD and LB did not differ in rate of decrease nor were there any effects related to age or general morbidity. Decrease in five of these cytokines (IFNγ, IL‐1β, IL‐2, IL‐4, and IL‐10) was highly correlated with decrease in cognition ( P < .003). Conclusions Peripheral inflammation decreased in both disease groups during MCI suggesting this may be a therapeutic window for future anti‐inflammatory agents.