Premium
Memory impairment and Alzheimer's disease pathology in individuals with MCI who underestimate or overestimate their decline
Author(s) -
Bregman Noa,
Kavé Gitit,
Zeltzer Ehud,
Biran Iftah
Publication year - 2020
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.5274
Subject(s) - cognitive decline , alzheimer's disease neuroimaging initiative , alzheimer's disease , psychology , memory impairment , neuroimaging , disease , cognitive impairment , memory clinic , cognition , gerontology , medicine , dementia , psychiatry , pathology
Objectives The aim of this study was to examine whether the discrepancy between participant and informant estimation of memory decline can predict MCI prognosis. Methods Analyses involved data from individuals with MCI enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who filled the Everyday Cognition questionnaire. Participants who underestimated (N = 112) and overestimated (N = 157) their memory decline were compared on memory tasks, brain volume, and cerebrospinal markers, at study entry and after 24 months. Results Individuals who underestimated their memory decline performed more poorly on memory tests, had smaller hippocampus volume, and greater Alzheimer's disease pathology than did individuals who overestimated their cognitive decline. Longitudinal comparisons demonstrated that individuals who underestimated their decline deteriorated more significantly in memory and in brain measures. Conclusions Underestimation of memory decline should raise clinicians' suspicion of the existence of AD pathology in individuals with MCI.