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Regional brain volume reductions in major depressive disorder and bipolar disorder: An analysis by voxel‐based morphometry
Author(s) -
Niida Richi,
Yamagata Bun,
Matsuda Hiroshi,
Niida Akira,
Uechi Akihiko,
Kito Shinsuke,
Mimura Masaru
Publication year - 2019
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.5009
Subject(s) - major depressive disorder , bipolar disorder , voxel based morphometry , voxel , psychology , anterior cingulate cortex , receiver operating characteristic , medicine , magnetic resonance imaging , psychiatry , neuroscience , amygdala , white matter , cognition , radiology
Objectives The present study investigated the usefulness of evaluating the existence of volume reduction in brain regions using voxel‐based morphometry (VBM) to dissociate major depressive disorder (MDD) from bipolar disorder (BD). Methods/Design This study enrolled 92 individuals with MDD, 32 individuals with BD, and 43 healthy controls (HCs). We focused on gray matter volume (GMV) of the subgenual anterior cingulate cortex (sgACC), subcallosal area (SCA), and hippocampus. The degree of volume reduction in these brain regions was calculated as the z score, and the differences of z scores in these regions were investigated among the MDD, BD, and HC groups. We then performed a receiver operating characteristic curve analysis to dissociate the individuals with MDD and BD from the HCs based on the z scores in the GMV of these brain regions. Results While there were no significant differences in the z scores of the hippocampus among the three groups, the z score of the sgACC was significantly higher in the MDD group than in the BD and HC groups, and the SCA z score was significantly higher in the MDD and BD groups than in the HC group. Conclusions Our findings suggest that VBM evaluation of GMV reduction in the sgACC may be useful as an objective adjunctive tool to distinguish between MDD and BD.