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Left dorsolateral prefrontal cortex atrophy is associated with frontal lobe function in Alzheimer's disease and contributes to caregiver burden
Author(s) -
Matsuoka Kiwamu,
Yasuno Fumihiko,
Hashimoto Akiko,
Miyasaka Toshiteru,
Takahashi Masato,
Kiuchi Kuniaki,
Iida Junzo,
Kichikawa Kimihiko,
Kishimoto Toshifumi
Publication year - 2018
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4843
Subject(s) - frontal lobe , dementia , dorsolateral prefrontal cortex , caregiver burden , psychology , correlation , prefrontal cortex , voxel , biomarker , alzheimer's disease , atrophy , cognition , audiology , medicine , disease , neuroscience , biochemistry , chemistry , geometry , mathematics , radiology
Objective Caregivers of patients with dementia experience physical and mental deterioration. We have previously reported a correlation between caregiver burden and the Frontal Assessment Battery (FAB) total scores of patients with Alzheimer's disease (AD), especially regarding the dependency factor from the Zarit Burden Interview. The present study aimed to identify an objective biomarker for predicting caregiver burden. Methods The participants were 26 pairs of caregivers and patients with AD and mild‐to‐moderate dementia. Correlations between regional gray matter volumes in the patients with AD and the FAB total scores were explored by using whole‐brain voxel‐based morphometric analysis. Path analysis was used to estimate the relationships between regional gray matter volumes, FAB total scores, and caregiver burden based on the Zarit Burden Interview. Results The voxel‐based morphometric revealed a significant positive correlation between the FAB total scores and the volume of the left dorsolateral prefrontal cortex. This positive correlation persisted after controlling for the effect of general cognitive dysfunction, which was assessed by using the Mini‐Mental State Examination. Path analysis revealed that decreases in FAB scores, caused by reduced frontal lobe volumes, negatively affected caregiver burden. Conclusions The present study revealed that frontal lobe function, based on FAB scores, was affected by the volume of the left dorsolateral prefrontal cortex. Decreased scores were associated with greater caregiver burden, especially for the dependency factor. These findings may facilitate the development of an objective biomarker for predicting caregiver burden.