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High proportions of dementia among SLE patients: A big data analysis
Author(s) -
Gendelman Omer,
Tiosano Shmuel,
Shoenfeld Yehuda,
Comaneshter Doron,
Amital Howard,
Cohen Ar D.,
Amital Daniela
Publication year - 2018
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4819
Subject(s) - dementia , odds ratio , medicine , univariate analysis , multivariate analysis , logistic regression , confidence interval , lupus erythematosus , systemic lupus erythematosus , disease , systemic disease , immunology , antibody
Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting a wide range of systems including the peripheral and central nervous system. Cognitive impairment leading to dementia is one of the harmful central nervous system afflictions of SLE. The aim of this study was to investigate the association of SLE with dementia. Methods A cross‐sectional study was conducted using Clalit Health Care database, the largest health maintenance organization in Israel with more than 4.4 million enrollees. Systemic lupus erythematosus patients were compared in a 1:5 ratio to age‐ and sex‐matched controls. Chi‐square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. Results The study included 4886 SLE patients and 24 430 age‐frequency‐ and sex‐frequency‐matched controls without SLE. The proportion of dementia was higher among SLE patients compared to controls (1.56% and 0.51%, respectively; P < .001). This finding was consistent across all age groups by univariate analysis. In a multivariate logistic regression analysis, SLE was significantly associated with dementia (odds ratio = 1.51, 95% confidence interval, 1.11‐2.04). Conclusion Systemic lupus erythematosus is significantly associated with dementia. This finding should give rise to search for SLE in patients with an ambiguous cause for dementia, especially those with an early onset cognitive decline.