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Increased N200 and P300 latencies in cognitively impaired elderly carrying ApoE ε‐4 allele
Author(s) -
Cintra Marco Túlio Gualberto,
Ávila Rafaela Teixeira,
Soares Thayana Oliveira,
Cunha Luciana Cristina Matos,
Silveira Katia Daniela,
Moraes Edgar Nunes,
Simas Kaique Roger,
Fernandes Renato Bragança,
Gonçalves Denise Utsch,
Rezende Nilton Alves,
Bicalho Maria Aparecida Camargos
Publication year - 2018
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4773
Subject(s) - audiology , dementia , psychology , cognition , neuropsychology , apolipoprotein e , rs6265 , cognitive impairment , medicine , neuroscience , brain derived neurotrophic factor , disease , neurotrophic factors , receptor
Objective To compare the results of neuropsychological tests, evoked potentials N200 and P300 and polymorphisms of ApoE and BDNF rs6265 between patients with normal cognition and those with mild cognitive impairment (MCI) and Alzheimer's dementia (AD). Methods This is a cross‐sectional study of elderly individuals with normal cognition and those with MCI and AD, who were submitted to evoked potential tests (N200 and P300) by means of hearing stimuli based on the auditory oddball paradigm. Genotyping was obtained by using the real‐time PCR technique. Results Sixty‐five patients were evaluated as follows: 14 controls, 34 with MCI and 17 with AD. N200 latency and P300 latency and amplitude were not associated with MCI and AD diagnosis. Patients with cognitive impairment (MCI or AD) showed increase in the latencies of P300 and N200. BNDF gene was not associated with cognitive impairment. Conclusion Latencies of N200 and P300 increased in cognitively impaired patients with the presence of ApoE ε‐4 allele.