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Mutual effect of cerebral amyloid β and peripheral lymphocytes in cognitively normal older individuals
Author(s) -
Yasuno Fumihiko,
Kazui Hiroaki,
Kajimoto Katsufumi,
Ihara Masafumi,
Morita Naomi,
Taguchi Akihiko,
Yamamoto Akihide,
Matsuoka Kiwamu,
Takahashi Masato,
Nakagawara Jyoji,
Tsuji Masahito,
Iida Hidehiro,
Kishimoto Toshifumi,
Nagatsuka Kazuyuki
Publication year - 2017
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4660
Subject(s) - cytotoxic t cell , pittsburgh compound b , peripheral , flow cytometry , dementia , immune system , cd8 , medicine , immunology , pathology , chemistry , psychology , disease , biochemistry , in vitro
Objective We hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre‐dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro‐inflammation. We aimed to determine whether peripheral lymphocytes are related to the cortical amyloid burden or vice versa in cognitively normal older subjects. Methods We applied [ 11 C] Pittsburgh compound B (PiB)‐positron emission tomography to 36 cognitively normal older individuals, and Aβ deposition was quantified by cortical binding potential (PiB‐BP ND ). Blood samples were obtained, and lymphocyte subsets were evaluated. We examined differences between low and high PiB‐BP ND groups in the percentage of B cells, T cells, helper T cells, cytotoxic T cells, regulatory T cells, and natural killer cells .Results Subjects with high PiB‐BP ND showed significantly higher percentage of cytotoxic T cells (%CD3 + ). Correlation analysis revealed a significant relationship between the percentage of cytotoxic T cells and global cortical mean PiB‐BP ND . Hierarchical regression analyses showed that cytotoxic T cells were significantly related to the value of global cortical mean PiB‐BP ND and vice versa. Conclusions Our results indicated that a specific peripheral immune response, reflected in the increased ratio of cytotoxic T cells, could be regarded as a preclinical sign of AD and could be attributed to the Aβ neuropathological mechanism. Copyright © 2017 John Wiley & Sons, Ltd.