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Anticholinergic effect on cognition (AEC) of drugs commonly used in older people
Author(s) -
Bishara Delia,
Harwood Daniel,
Sauer Justin,
Taylor David M.
Publication year - 2017
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4507
Subject(s) - anticholinergic , dementia , cognition , medicine , older people , drug , psychology , gerontology , psychiatry , disease
Objective Use of anticholinergic drugs in older people is associated with increased risk of cognitive decline and of dementia and death. Method We identified drugs widely used in older people and attempted to classify their anticholinergic effect on cognition (AEC) according to our three‐point scale which scored AEC according to in vitro anticholinergic potency, capacity to cross the blood–brain barrier and statements made in standard texts. Results In total, 165 drugs were examined. We identified 21 drugs with an AEC score of 3, 18 with a score of 2, 21 with a score of 1 and 62 with a score of 0. Owing to insufficient information, we were unable to classify 43 drugs. Conclusions A large number of drugs commonly used in older people are likely to be associated with cognitive impairment. Copyright © 2016 John Wiley & Sons, Ltd.