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Amyloid burden and incident depressive symptoms in cognitively normal older adults
Author(s) -
Harrington Karra D.,
Gould Emma,
Lim Yen Ying,
Ames David,
Pietrzak Robert H.,
Rembach Alan,
RaineySmith Stephanie,
Martins Ralph N.,
Salvado Olivier,
Villemagne Victor L.,
Rowe Christopher C.,
Masters Colin L.,
Maruff Paul
Publication year - 2017
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4489
Subject(s) - depression (economics) , geriatric depression scale , neuroimaging , medicine , incidence (geometry) , prospective cohort study , late life depression , confidence interval , alzheimer's disease , disease , depressive symptoms , psychiatry , cognition , physics , optics , economics , macroeconomics
Objective Several studies have reported that non‐demented older adults with clinical depression show changes in amyloid‐β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54‐month prospective observation period. Methods Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ ( n = 81) or low Aβ ( n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale — Short Form at 18‐month intervals over 54 months. Results Whilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95% confidence interval [CI] 1.3–16.4) times greater within the high Aβ group (9%) than the low Aβ group (2%) by the 54‐month assessment. Conclusions Results of this study suggest that elevated Aβ levels are associated with a 4.5‐fold increased likelihood of developing clinically significant depressive symptoms on follow‐up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ. Copyright © 2016 John Wiley & Sons, Ltd.